In men, approximately 5% of testosterone undergoes 5a-reduction to form the more potent androgen, dihydrotestosterone DHT, is a male sex hormone, an androgen. 5a-reductase, an enzyme, synthesizes DHT in the adrenal glands, hair follicles, testes and prostate. Male and female adults can lose hair as a consequence of changes in the metabolism of androgen in the body - men more commonly than women. DHT plays a major role in hair loss. Experts say that 95% of cases of male pattern baldness occur because of the effects of DHT on the hair follicles. How much DHT people produce depends almost entirely on their genetic make-up - the more that is produced, the greater and more widespread miniaturization is, resulting in greater hair loss.